Prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database

PURPOSE: There is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. The aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients. METHODS: This study included 362 patients operated in a single institution for Dukes A and B (node-negative) colorectal cancer. The median follow-up was 140 months. The prognostic value of 13 clinical and pathological parameters was investigated. RESULTS: Multivariate analysis identified six independent prognostic factors: age at time of diagnosis (hazard ratio (HR) = 1.076), number of lymph nodes removed (HR = 0.948), perineural invasion (HR = 2.173), venous invasion (HR = 1.959), lymphatic vessel invasion (HR = 2.126), and T4 stage (HR = 5.876). CONCLUSION: These parameters could be useful in identifying patients with high-risk node-negative colorectal cancer who should be presented to adjuvant therapy

The Extended Baryon Oscillation Spectroscopic Survey: Variability Selection and Quasar Luminosity Function

The SDSS-IV/eBOSS has an extensive quasar program that combines several selection methods. Among these, the photometric variability technique provides highly uniform samples, unaffected by the redshift bias of traditional optical-color selections, when $z= 2.7 - 3.5$ quasars cross the stellar locus or when host galaxy light affects quasar colors at $z < 0.9$. Here, we present the variability selection of quasars in eBOSS, focusing on a specific program that led to a sample of 13,876 quasars to $g_{\rm dered}=22.5$ over a 94.5 deg$^2$ region in Stripe 82, an areal density 1.5 times higher than over the rest of the eBOSS footprint. We use these variability-selected data to provide a new measurement of the quasar luminosity function (QLF) in the redshift range $0.68<z<4.0$. Our sample is denser, reaches deeper than those used in previous studies of the QLF, and is among the largest ones. At the faint end, our QLF extends to $M_g(z\!=\!2)=-21.80$ at low redshift and to $M_g(z\!=\!2)=-26.20$ at $z\sim 4$. We fit the QLF using two independent double-power-law models with ten free parameters each. The first model is a pure luminosity-function evolution (PLE) with bright-end and faint-end slopes allowed to be different on either side of $z=2.2$. The other is a simple PLE at $z<2.2$, combined with a model that comprises both luminosity and density evolution (LEDE) at $z>2.2$. Both models are constrained to be continuous at $z=2.2$. They present a flattening of the bright-end slope at large redshift. The LEDE model indicates a reduction of the break density with increasing redshift, but the evolution of the break magnitude depends on the parameterization. The models are in excellent accord, predicting quasar counts that agree within 0.3\% (resp., 1.1\%) to $g<22.5$ (resp., $g<23$). The models are also in good agreement over the entire redshift range with models from previous studies.Comment: 15 pages, 12 figures, accepted for publication in A&

New pixelized Micromegas detector for the COMPASS experiment

New Micromegas (Micro-mesh gaseous detectors) are being developed in view of the future physics projects planned by the COMPASS collaboration at CERN. Several major upgrades compared to present detectors are being studied: detectors standing five times higher luminosity with hadron beams, detection of beam particles (flux up to a few hundred of kHz/mm^2, 10 times larger than for the present detectors) with pixelized read-out in the central part, light and integrated electronics, and improved robustness. Studies were done with the present detectors moved in the beam, and two first pixelized prototypes are being tested with muon and hadron beams in real conditions at COMPASS. We present here this new project and report on two series of tests, with old detectors moved into the beam and with pixelized prototypes operated in real data taking condition with both muon and hadron beams.Comment: 11 pages, 5 figures, proceedings to the Micro-Pattern Gaseous Detectors conference (MPGD2009), 12-15 June 2009, Kolympari, Crete, Greece Minor details added and language corrections don

First electron beam polarization measurements with a Compton polarimeter at Jefferson Laboratory

A Compton polarimeter has been installed in Hall A at Jefferson Laboratory. This letter reports on the first electron beam polarization measurements performed during the HAPPEX experiment at an electron energy of 3.3 GeV and an average current of 40 $\mu$A. The heart of this device is a Fabry-Perot cavity which increased the luminosity for Compton scattering in the interaction region so much that a 1.4% statistical accuracy could be obtained within one hour, with a 3.3% total error

Possible measurements of GPDs at COMPASS

This paper presents the reactions which can be performed at COMPASS to study the Generalized Parton Distributions (GPDs). The high energy muon beam at CERN allows to measure Hard Exclusive Meson Production or Deeply Virtual Compton Scattering (DVCS) in the Bjorken regime in a large range of Q^2 and x_Bj (1.5<Q^2<7.5 GeV^2 and 0.03<x_Bj<0.25). Exploratory measurements dedicated to rho_0 or pi_0 production can be investigated with the present setup. DVCS measurement require an upgrade of the COMPASS setup.Comment: 20 pages, 9 figure

A photon calorimeter using lead tungstate crystals for the CEBAF Hall A Compton polarimeter

The performances of the calorimeter of the Jlab Hall A Compton Polarimeter have been measured using the Mainz tagged photon beam.Comment: 13 page

New pixelized Micromegas detector with low discharge rate for the COMPASS experiment

New Micromegas (Micro-mesh gaseous detectors) are being developed in view of the future physics projects planned by the COMPASS collaboration at CERN. Several major upgrades compared to present detectors are being studied: detectors standing five times higher luminosity with hadron beams, detection of beam particles (flux up to a few hundred of kHz/mm^{2}, 10 times larger than for the present Micromegas detectors) with pixelized read-out in the central part, light and integrated electronics, and improved robustness. Two solutions of reduction of discharge impact have been studied, with Micromegas detectors using resistive layers and using an additional GEM foil. Performance of such detectors has also been measured. A large size prototypes with nominal active area and pixelized read-out has been produced and installed at COMPASS in 2010. In 2011 prototypes featuring an additional GEM foil, as well as an resistive prototype, are installed at COMPASS and preliminary results from those detectors presented very good performance. We present here the project and report on its status, in particular the performance of large size prototypes with an additional GEM foil.Comment: 11 pages, 5 figures, proceedings to the Micro-Pattern Gaseous Detectors conference (MPGD2011), 29-31 August 2011, Kobe, Japa